CAESAR III
The boys and I bought a $10 copy of a game called "Caesar II" back in the Windows 95 era. The box promised that you could build a city, build an empire, and then go out and kick barbarian ass, but we could never get the city built before it would burn down or get the plague.
The game had one notable feature: Every few minutes, a voice would announce "PLEBS ARE NEEDED! PLEBS ARE NEEDED!" and keep repeating that, like a car alarm, until you fixed your "Plebs" slider.
So it became a running joke around the house that the worst sequel of all time would be "CAESAR III," with its obvious pitchline: "PLEBS ARE STILL NEEDED."
You've got to be a mega-geek to get this joke, but there are more than a few out there.